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The hypotensiveaction is more marked after parenteral adminis-tration and roughly parallels the adrenergicblocking potency. Sometimes it is an inflammatorysetting or it can be an antagonistic situation where the tumor is shedding partial immunogenicpeptides causing the T cell receptor (TCR) to negatively alter T cell function (Haribhai 2004).This situation could potentially lead to non-cancer related autoimmune responses. Among 500 arthritis episodes, we analyzed196 immunocompromised patients and 69 with gout or other crystal arthropathy.Gram staining revealed pathogens in 146 episodes (146/500, 29%) or in 146 of the 400culture-positive episodes (37%). Theadjusted OR becomes 0.61 (39% risk reduction), and still represents a clinicallyimportant effect

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